Maik Hadorn

ETH Zurich
Department of Chemistry and Applied Biosciences
HCI E 323
Wolfgang-Pauli-Str. 10
8093 Zurich
Switzerland


Tel: +41 44 633 76 50
E-Mail: maik.hadorn (at) org.chem.ethz.ch 
WEB: http://www.dittrich.ethz.ch/people/CurrMemb/Hadorn 
ResearcherID: http://www.researcherid.com/rid/I-8909-2012

Research Interests

I am a biologist with a strong background in bio-inspired materials and processes, connecting biology with technology. Focusing on the spatial and temporal organization of natural systems, my research is centered around artificial vesicles and emulsion droplets. I have developed DNA as smart glue along with reliable preparation techniques to engineer both higher-order vesicle and emulsion droplet structures as novel smart materials and tissue mimics as well as artificial vesicles with controlled internal architecture as multicompartment drug delivery systems and elaborated cell mimics.

Starting with my doctoral thesis at the Artificial Intelligence Laboratory (2006-2010; University of Zurich, Switzerland), I continued my work on artificial biomimetic structures during my postdoctoral positions at the Center for Fundamental Living Technology (2010-2012; University of Southern Denmark, Denmark) and currently at the Swiss Federal Institute of Technology Zurich, ETH (Switzerland).

Over the last two years, I published several contributions to scientific journals (PNAS, Nature Scientific Reports, PLoS one) and presented my work at numerous conferences ranging in topics from artificial life to personalized medicine.

I have been an active participant in two EU-sponsored collaborative projects (Programmable Artificial Cell Evolution, MATrix for Chemical IT), and I established a broad international network of collaborations with well-respected researchers.

CV

Scientific Employment


2012 -
Postdoctoral research fellow, Bioanalytics Group, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich, ETH, Zurich, Switzerland.

2010 - 2012
Postdoctoral research fellow, FLinT Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, Denmark. Supported by the Swiss National Foundation: Post-doctoral fellowships for prospective researchers.

2005 - 2010
Teaching assistant / Doctoral student, Artificial Intelligence Laboratory, Department of Informatics, University of Zurich, Switzerland.

2002 – 2003
Tutor, Mathematical Institute, University of Zurich, Switzerland.

Education

2005 – 2010
Doctoral Thesis (equivalent to PhD) at the Faculty of Science (MNF), University of Zurich, Switzerland. Thesis: ‘Field-Programmable Assemblies of Artificial Cells as Instances of a new Embedded Living Information Communication Technology’ supported by the Swiss National Foundation.

2004 – 2005
Diploma Thesis (equivalent to MSc) in Biology (Zoology), University of Zurich, Switzerland. Thesis: ‘Combining Genetical, Developmental, and Evolutionary Processes in an Artificial System to Evolve the Morphology of the Precambrian fossil Dickinsonia costata’.

2000 – 2004
Studies in Biology, University of Zurich, Switzerland.

1992 – 2000
Gymnasium Solothurn (grammar school graduation), Switzerland.

Publications

Journal Papers

Hadorn M, Boenzli E, Sørensen KT, Fellermann H, Eggenberger Hotz P, Hanczyc MM (2012). Specific and Reversible DNA-directed Self-Assembly of Oil-in-Water Emulsion Droplets. Proc. Natl. Acad. Sci. U. S. A.

Hadorn M, Boenzli E, Eggenberger Hotz P, Hanczyc MM (2012). Hierarchical Unilamellar Vesicles of Controlled Compositional Heterogeneity. PLoS One 7(11):e50156.

Hadorn, M., Boenzli, E., Eggenberger Hotz, P (2011). A quantitative analytical method to test for salt effects on giant unilamellar vesicles. Sci. Rep. 1.

Hadorn M* and Eggenberger Hotz P (2010). DNA-Mediated Self-Assembly of Artificial Vesicles. Plos One 5(3):e9886.

Conference Proceedings

Fellermann H, Hadorn M, Boenzli E, Rasmussen S (2012). Integrating Molecular Computation and Material Production in an Artificial Subcellular Matrix. Biomimetic and Biohybrid Systems. Proceedings. First International Conference, Living Machines 2012:343-344344.

Hadorn M* and Hotz PE (2011). Encapsulated Multivesicle Assemblies of Programmable Architecture: Towards Personalized Healthcare, in Biomedical Engineering Systems and Technologies, A Fred, J Filipe, and H Gamboa, Editors, Springer-Verlag Berlin: Berlin. p. 141-151.

Boenzli E*, Hadorn M, Eggenberger Hotz P (2010). Meta-Engineering in Drug Design: A Roadmap to Implement a Novel Liposome-Based Testbed. In International Conference on Engineering and Meta-Engineering (ICEME 2010), Orlando, USA, April 6th - 9th, 2010.

Koller-Hodac A, Germann DP*, Gilgen A, Dietrich K, Hadorn M, Schatz W, Hotz PE (2010). Actuated Bivalve Robot Study of the Burrowing Locomotion in Sediment, in 2010 Ieee International Conference on Robotics and Automation, M Ra-kotondrabe and IA Ivan, Editors, Ieee: New York. p. 1209-1214.

Hadorn M*, Burla B, and Eggenberger Hotz P (2009). Towards Tailored Communication Networks in Assemblies of Artificial Cells, in LNAI, vol. 5865, K Korb, M Randall, and T Hendtlass, Editors, Springer: Heidelberg. p. 126-135.

Hadorn M* and Eggenberger Hotz P (2009). Multivesicular Assemblies as Real-World Testbeds for Embryogenic Evolutionary Systems, in LNAI, vol. 5865, K Korb, M Randall, and T Hendtlass, Editors, Springer: Heidelberg. p. 169-178.

Rinderknecht M*, Ruesch J, Hadorn M (2007). The Lagging Legs - Exploiting Body Dynamics to Steer a Quadrupedal Agent. in Proceedings of the International Conference on Morphological Computation (ICMC07) p: 82-85, European Center for Living Technology, Ca' Minich, Venice, Italy.

Miyashita S*, Eggenberger Hotz P, Hadorn M (2007). Water Floating Self-Assembling Agents. The 1st KES International Symposium on Agent and Multi-Agent Systems - Technologies and Applications (KES-AMSTA 2007). 2007. Wroclaw, Poland. Agent and Multi-Agent Systems: Technologies and Applications, Proceedings p: 665-674, ISBN: 978-3-540-72829-0. Springer-Verlag Berlin.

Miyashita S*, Eggenberger Hotz P, Hadorn M (2007). Self-Assemble of Water Floating Active Units. In The IEEE International Conference on Mechatronics (ICM) p: 548-553, ISBN: 978-1-4244-1183-2, Kumamoto, Japan.

Miyashita S*, Eggenberger Hotz P, Hadorn M (2007). Tribolon - Water Floating Self-Assembling Units. in Proceedings of the International Conference on Morphological Computation (ICMC07) p: 51-53, European Center for Living Technology, Ca' Minich, Venice, Italy.

Hadorn M*, Schatz W, Eggenberger Hotz P (2004). Were Adam and Eve Ediacarans? - A possible sexual dimorphism in Dickinsonia costata. in Abstracts of the 2nd Swiss Geoscience Meeting, p:164.

Peer Reviewed Posters

Hadorn M, Boenzli E, Sørensen KT, De Lucrezia D, Hanczyc MM, Yomo T. Gene Expression in Synthetic Micro- and Macro-Tissues. Swiss Soft Days 9, 29 October 2012, Nestlé Research Center, Lausanne, Switzerland.

Boenzli E*, Hadorn M, de Lucrezia D, Jørgensen MG, Eggenberger Hotz P, Hanczyc MM, Yomo T (2012). Genetically controlled fusion, exocytosis and fission of artificial vesicles - a roadmap. Up Close and Personalized International Congress on Personalized Medicine (UPCP),  2-5 February 2012, Florence, Italy.

Boenzli E*, Hadorn M, de Lucrezia D, Jørgensen MG, Eggenberger Hotz P, Hanczyc MM, Yomo T (2011). Genetically controlled fusion, exocytosis and fission of artificial vesicles. International Symposium on Synthesizing Life and Biological Systems, 24-26 October 2011, Osaka, Japan.

Hadorn M*, Boenzli E, Hanczyc MM, Eggenberger Hotz P (2011). Multicompartment Drug Delivery Systems: On the Way of Entering the Mainstream. The Sixth Danish Conference on Biotechnology and Molecular Biology: Synthetic Biology and Cell Factories, 26-27 May 2011, Vejle, Denmark.

Boenzli E*, Hadorn M, Jørgensen MG, Eggenberger Hotz P, Hanczyc MM, Yomo T (2011). A scenario for a genetically controlled fission of artificial vesicles. The Sixth Danish Conference on Biotechnology and Molecular Biology: Synthetic Biology and Cell Factories, 26-27 May 2011, Vejle, Denmark.

Hadorn M*, Boenzli E, Eggenberger Hotz P (2010). Does Systems Biology have to get Wet? How Gene Expression in Mul-tivesicle Assemblies could be used to validate in silico Results. EMBO Workshop in Systems Biology of Development, 16-20 August 2010, Ascona, Switzerland.

Hadorn M (2004). Were Adam and Eve Ediacarans? - A possible sexual dimorphism in Dickinsonia costata. Swiss Geos-cience Meeting, 19-20 November 2004, Lausanne, Switzerland.

Peer Reviewed Presentations

An Artificial Multivesicular In Vitro System to Emulate Multicellular Processes. Artificial Life 13, 19-22 July 2012, Michigan State University, East Lansing Michigian, US. Synthetic Biology, Best Presentation Award.

Specifically Assembled Emulsion Droplets as a Novel Multicompartment Delivery System. Up Close and Personalized International Congress on Personalized Medicine (UPCP),  2-5 February 2012, Florence, Italy.

Encapsulated Multi-vesicle Assemblies of Programmable Architecture: Towards Personalized Healthcare. The Third International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2010), 20-23 January 2010, Valencia, Spain.

Towards Tailored Communication Networks in Assemblies of Artificial Cells. The Fourth Australian Conference on Artificial Life (ACAL'09), 1-4 December 2009, Melbourne, Australia.

Multivesicular Assemblies as Real-World Testbeds for Embryogenic Evolutionary Systems. The Fourth Australian Conference on Artificial Life (ACAL'09), 1-4 December 2009, Melbourne, Australia.