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Martin Hanczyc

Institute of Physics Chemistry and Pharmacy
University of Southern Denmark
Campusvej 55
5230 Odense M
Denmark

Tel +45 6550 4438
FAX +45 6615 8760
Email: martin@sdu.dk



Research Interests

NEWS:

I presented a keynote lecture at ECAL 2013 in Italy which was covered by WIRED:
http://www.wired.co.uk/news/archive/2013-09/06/generative-chemistry-origins-of-life

 

New papers:

Andersen JK, Andersen T, Flamm C, Hanczyc MM, Merkle D, Stadler PF.  2013.  Navigating the Chemical Space of HCN Polymerization and Hydrolysis: Guiding Graph Grammars by Mass Spectrometry Data. Entropy.15(10), 4066-4083.

Armstrong R, Hanczyc MM. 2013.  Bütschli Dynamic Droplet System. Artificial Life, 19(3-4): 331-346.

Caschera F, Rasmussen S, Hanczyc MM.  2013. An Oil Droplet Division-Fusion Cycle, ChemPlusChem, DOI: 10.1002/cplu.201200275.

Hadorn M, Boenzli E, Sørensen KT, Fellermann H, Eggenberger Hotz P, Hanczyc MM. 2012. Specific and Reversible DNA-directed Self-Assembly of Oil-in-Water Emulsion Droplets. PNAS, doi: 10.1073/pnas.1214386109.

Hadorn M, Boenzli E, Eggenberger Hotz P, Hanczyc MM. 2012. Hierarchical Unilamellar Vesicles of Controlled Compositional Heterogeneity, PLoS ONE, 7(11) e50156.

Caschera F, Bernardino de la Serna J, Loffler PMG, Rasmussen TE, Hanczyc MM, Bagatolli LA, Monnard P-A. 2011. Stable Vesicles Composed of Monocarboxylic or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles, Langmuir, dx.doi.org/10.1021/la203057b

Caschera F, Sunami T, Matsuura T, Suzuki H,. Hanczyc MM, Yomo T. 2011. Programmed Vesicle Fusion Triggers Gene Expression. Langmuir 2011, 27, 13082–13090.

Hanczyc MM. 2011. Metabolism and motility in prebiotic structures. Phil. Trans. R. Soc. B, 366, 2885-2893. doi: 10.1098/rstb.2011.0141

Caschera F, Bedau MA, Buchanan A, Cawse J, de Lucrezia D, Gazzola G, Hanczyc MM, Packard N. 2011. Coping With Complexity: Machine Learning Optimization of Cell-Free Protein Synthesis. Biotechnology and Bioengineering. 108 (9) 2218–2228.

Horibe N, Hanczyc MM and Ikegami T. 2011. Mode Switching and Collective Behavior in Chemical Oil Droplets. Entropy 13, 709-719; doi:10.3390/e13030709

CV and Bibliography

CURRENT POSITIONS

Associate Professor April 2008-present

Institute of Physics Chemistry and Pharmacy, University of Southern Denmark


 

RECENT POSITIONS

Honorary Senior Lecturer Sept 2009-Aug 2012

The Bartlett School of Architecture, University College London

Visiting Professor, Tokyo University, Komaba March, April 2009

Laboratory Director October 2007-Feb 2008

The European Center for Living Technology in Venice, Italy

Chief Chemist March 2005 – April 2008

ProtoLife Srl in Venice, Italy.  Director of research in membrane dynamics and complex chemical systems.

 

EDUCATION

Harvard University, Boston, Massachusetts.                                                        Sept. 1999 – March 2005

Postdoctoral Fellow

Developed a system of vesicle reproduction and studied the role of membranes and minerals in the origin of life.

Dr. Jack W. Szostak, Mentor.

Yale University, New Haven, Connecticut.                                                                    August 1992 – May 1999

Ph.D. in Genetics.

Dissertation : Exploration of Diversity, Adaptation and Complexity in

Experimental Systems of Evolution In Vitro

Dr. Robert L. Dorit, Mentor.

Pennsylvania State University, State College, PA.                                                      August 1988 - May 1992

BS. in Biology May 1992.  Concentration in Genetics and Development.

Graduated with honors.   GPA 3.75.

 

PUBLICATIONS

Caschera F, Bernardino de la Serna J, Loffler PMG, Rasmussen TE, Hanczyc MM, Bagatolli LA, Monnard P-A. 2011. Stable Vesicles Composed of Monocarboxylic or Dicarboxylic Fatty Acids and Trimethylammonium Amphiphiles, Langmuir, dx.doi.org/10.1021/la203057b

Caschera F, Sunami T, Matsuura T, Suzuki H,. Hanczyc MM, Yomo T. 2011. Programmed Vesicle Fusion Triggers Gene Expression. Langmuir 2011, 27, 13082–13090.

Hanczyc MM. 2011. Metabolism and motility in prebiotic structures. Phil. Trans. R. Soc. B, 366, 2885-2893. doi: 10.1098/rstb.2011.0141

Caschera F, Bedau MA, Buchanan A, Cawse J, de Lucrezia D, Gazzola G, Hanczyc MM, Packard N. 2011. Coping With Complexity: Machine Learning Optimization of Cell-Free Protein Synthesis. Biotechnology and Bioengineering. 108 (9) 2218–2228.

Horibe N, Hanczyc MM and Ikegami T. 2011. Mode Switching and Collective Behavior in Chemical Oil Droplets. Entropy 13, 709-719; doi:10.3390/e13030709

Hanczyc MM. 2010.  Chapter contribution. In M. A. Bedau, P. Guldborg Hansen, E. Parke, S. Rasmussen, (Eds.) Living Technology, 5 Questions. Automatic  Press. pp 77-84.

Hanczyc MM and Ikegami T. 2010. Emergence of Self-Movement as a Precursor to Darwinian Evolution. OLEB 40(4-5): 383. Conference abstract.

Sunami T, Caschera F, Morita Y, Toyota T, Nishimura K, Matsuura T, Suzuki H, Hanczyc MM, Yomo T. 2010. Detection of Association and Fusion of Giant Vesicles Using a Fluorescence-Activated Cell Sorter, Langmuir 26(19), 15098–15103.

Hanczyc MM and Ikegami T. 2010. Chemical basis for minimal cognition. Artificial Life 16: 233–243.

Caschera F, Gazzola G, Bedau MA, Bosch Moreno C, Buchanan A, Cawse J, Packard N, Hanczyc MM. 2010. Automated Discovery of Novel Drug Formulations Using Predictive Iterated High Throughput Experimentation. PLoS ONE 5(1): e8546.doi:10.1371/journal.pone.0008546

Toyota T, Maru N, Hanczyc MM, Ikegami T, Sugawara T. 2009. Self-Propelled Oil Droplets Consuming “Fuel” Surfactant. J. Am. Chem. Soc., 2009, 131 (14), pp 5012–5013.

Hanczyc MM. 2008. The Early History of Protocells – the search for the recipe of life. In S. Rasmussen, M. A. Bedau, L. Chen, D. Deamer, D. C. Krakauer, N. H. Packard, & P. F. Stadler (Eds.) Protocells: Bridging Nonliving and Living Matter. MIT Press. pp 3-18.

Hanczyc MM, Chen IA, Sazani PL, Szostak JW.  2008. Steps toward a Synthetic Protocell. In S. Rasmussen, M. A. Bedau, L. Chen, D. Deamer, D. C. Krakauer, N. H. Packard, & P. F. Stadler (Eds.) Protocells: Bridging Nonliving and Living Matter. MIT Press.  pp 107-124.

Matsuno, H., Hanczyc, M.M., Ikegami, T. 2007. Self-maintained movements of droplets with convection flow. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 4828 LNAI, pp. 179-188

Hanczyc MM, Toyota T, Ikegami T, Packard N, Sugawara T.  2007. Fatty Acid Chemistry at the Oil-Water Interface: Self-Propelled Oil Droplets. J Am Chem Soc. 129(30):9386-91.

Hanczyc MM, Mansy SS, Szostak JW. 2006 Mineral surface directed membrane assembly Orig Life Evol Biosph. 37(1):67-82

Theis M, Gazzola G, Forlin M, Poli I, Packard N, Hanczyc MM, Bedau MA. 2006 Optimization of Complex Chemical Systems using a Genetic Algorithm ECCS ’06 Proceedings. ComPlexUs.

Chen IA, Hanczyc MM, Sazani PL, Szostak JW.  2006 Protocells: Genetic Polymers Inside Membrane Vesicles, in R.F. Gesteland, T.R. Cech, & J.F. Atkins (Eds.)The RNA World, Third Edition. (pp. 57-88). Cold Spring Harbor, NY: Cold Spring Harbor Press.

Bedau MA, Buchanan A, Gazzola G, Hanczyc MM, Maeke T, McCaskil J, Poli I, Packard NH. 2005. Evolutionary design of a DDPD model of ligation. In Proceedings of the 7th International Conference on Artificial Evolution EA'05. Lecture Notes in Computer Science, Springer Verlag.

Hanczyc MM and Szostak JW. 2004 Replicating vesicles as models of primitive cell growth and division. Curr Opin Chem Biol 8(6):660-4.

Hanczyc MM, Fujikawa SM, and Szostak JW. 2003 Experimental models of primitive cellular compartments: encapsulation, growth and division. Science 302: 618-622.

Hanczyc MM and Dorit RL.2000 Replicability and recurrence in the experimental evolution of a group I ribozyme.. Molecular Biology and Evolution.  17(7): 1050-1060.

Hanczyc MM and Dorit RL. 1998 Experimental evolution of complexity: in vitro emergence of intermolecular ribozyme interactions. RNA 4: 268-275.

Leicht BG, Muse SV, Hanczyc M, and Clark AG. January 1995 Constraints on intron evolution in the gene encoding the myosin alkali light chain in Drosophila. Genetics 139: 299-308.

Lu RB, Patstis AJ, Hanczyc MM, Chang FM, Rosenbaum HC, Thomas EL, Kidd JR, Kidd KK. 1993. A Directed Search for a Major Locus Underlying Manic-Depressive Disorder. American Journal of Human Genetics 53 (3): 1039.

Funding:

  • ERATO (JST) workpackage leader:  2011-2013
  • Matrix for Chemical IT (MATCHIT), European commission STREP, FP7-ICT-2009-4, workpackage leader 2010-2013
  • Dec. 2000 - 2004: National Institutes of Health, National Research Service Award
    Principal Investigator: Martin M. Hanczyc, Department of Molecular Biology, Harvard University Project Title: In Vitro Evolution of Multiple Turnover Catalysts
  • Sept. 1999 - Dec. 2000: Howard Hughes Medical Institute Postdoctoral Fellowship
    Program Director: Jack W. Szostak, Department of Molecular Biology, Harvard University.
  • May 1996 - April 1999: National Science Foundation Dissertation Improvement Grant
    Program Director: Robert Dorit, Yale University Award # 9623303.
  • Sept. 1992 - August 1995: Medical Informatics Training Grant
    Program Director: Perry Miller, Yale University. 5 T15 LM07056

Teaching, Misc

  • 2009 – present: Courses at SDU: Nanobioscience Technology, Bio-inorganic chemistry, Assembling minimal living systems, Philosophy of Science, Analytical Spectroscopy
  • Aug 2006: Lecturer, Short course on the Origin of Life, University of Tokyo, Komaba
  • Spring 2004: Lecturer, Astrobiology course (ASTR 403), Rice University
  • Spring 1996,1997,1998: Ecology and evolution laboratory. Yale University (BIO243LB )
    An undergraduate laboratory course exploring the evolution and ecology of antibiotic resistance in human bacteria, the origin and evolution of HIV, the evolution of mammalian and avian morphology, and the utility of human DNA forensic typing.
  • Spring 1995: Lecturer, Human genetics seminar. Yale University. (HG500A )
    A small seminar designed to introduce first year medical school students to a broad range of human genetic topics from disease inheritance to molecular techniques to ethical issues.
  • June - July 1994: Assistant Editor
    Sinauer Associates, Inc. Publishers, Sunderland, Massachusetts.

Honors:

  • 2008: Best Presented Work "Chemical basis for minimal cognition" Alife XI, Winchester
  • 1998 - 1999 G. Evelyn Hutchinson Prize, Yale Institute for Biospheric Studies
  • Plenary Session - Outstanding Young Investigators
    Presented "Evolving complexity in an in vitro ribozyme system" at the 9th International Congress on Isozymes, Genes and Gene Families. April 14-19, 1997.

Presentations (Invited, public):

  • The Path Towards Living Systems, TED Salon, London. May 18, 2011.

Invited keynote lecture

  • International Symposium on Nanoscale Pattern Formation at Surfaces, The Royal Danish Academy of Sciences and Letters, May 26-30, 2013, Copenhagen, Denmark
  • “The Droplets of Artificial Life: higher-order and far from equilibrium” 2nd Discussion Symposium on Artificial Life and Biomimetic Functional Materials, December 11, 2012, Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan
  • “Protocells and the Early Earth” 7th National Conference on Evolution. Middle Eastern Technical University, Sept 29-30, 2012. Ankara Turkey.

Presentations (Peer reviewed):

  • "Chemical basis for minimal cognition", M. Hanczyc and T. Ikegami, ALife XI August 4-8, 2008, Winchester, UK

Presentations (Invited speaker):

  • “Developing autonomous protocells: chemotaxis and group dynamics” Max Planck Focus Meeting: February 27-29, 2012. Saig, Germany.
  • "What can a simple oil droplet teach us about life?" January 31, 2012, Trinity College, Cambridge University
  • “Metabolism and motility in prebiotic structures” November 24, 2011, Astrobiology Society of Britain, Darwin College, Cambridge UK.
  • "Coupling chemistry to the body to engineer dynamic artificial life” September 13, 2011. Symposium on ‘Inorganic Biology and Protocells: Engineering Artificial Life’ Glasgow University
  • "Metabolism and motility in prebiotic structures" April 20, 2011 Origins of Life Initiative, Harvard University
  • "Metabolism and motility in prebiotic structures" April 7, 2011 Mads Clausen Institute, NanoSYD, Sønderborg, DK.
  • "Metabolism and motility in prebiotic structures" M Hanczyc. February 21-22. 2011. The Royal Society, London.
  • "Developing a primitive cell cycle with model membranes" M Hanczyc. December 15, 2010. Biophysical Unit. CSIC-UPV/EHU, Bilbao, Spain.
  • “Primitive chemotaxis in self-propelled oil droplets” M. Hanczyc. December 14, 2010. Department of Logic and Phil. of Science, FICE, UPV/EHU, San Sebastian, Spain.
  • “Chemical basis for minimal cognition” M. Hanczyc and T. Ikegami. November 24, 2010.  Embryo Physics Course, Second Life.
  • “Recent topics from construction of artificial cell by using oil droplets and vesicles” June 25, 2010.  University of Tokyo, Komaba.
  • “Protocells and computing?” First International Workshop on Computing with Spatio-Temporal Dynamics.  June 23-24, 2010.  Tokyo, Japan.
  • “Protocells and Architecture” Architecture and Unconventional Computing conference. The Bartlett School of Architecture, London. February 26, 2010.
  • “Artificial chemical ecologies?” Royal Academy of Fine Arts, School of Architecture, Copenhagen, Denmark. August 13, 2009.
  • “Minimal chemical life” Opening of the Initiative for Science, Society and Policy (ISSP) Louisiana, Denmark, June 11, 2009
  • “The study of motility in simple chemical systems” Tokyo University, March 23, 2009
  • “Protocells as smart agents for architectural design “ Systems Architecture conference, Bartlett School of Architecture, February 12, 2009, London.
  • “Soft robotics: autonomous movement in a simple chemical system” Brown Bag Talk as AI-Lab, University of Zurich. December 4, 2007
  • "A model chemical system to study the emergence of movement" Caltech Workshop on Self-Replicating Chemical Systems, August 27 - 28, 2007, Pasadena, CA
  • "Primitive Evolution: the emergence of movement in simple chemical systems" Max Planck Institute, June 9, 2007. Leipzig, Germany
  • "Simple Protocell Models" University of Southern Denmark, 16 April 2007, Odense Denmark
  • "An Oil Droplet Model To Study the Emergence of Cellular Movement" Osaka University, August 26, 2006, Osaka, Japan
  • "An Oil Droplet Model To Study the Emergence of Cellular Movement" Institute Josef Stefan, May 19, 2006. Ljubljana, Slovenia.
  • "Self-organization and replication of cell-like compartments" Hayashibara Forum, December 1-3, 2005. Okayama, Japan
  • "Formation and replication of protocellular compartments" COST D27 Workshop, September 28-October 1, 2005. Venezia, Italia
  • "Spontaneous Vesicle Growth and Division" PACE and PAs workshop. July 19-22, 2005 Los Alamos National Laboratory.USA
  • "Vesicle Growth and Division" PACE Workshop, February 23-27, 2005. Venezia, Italia
  • "Experimental models of primitive cellular organization: the role of clays and the dynamics of membranes." Life as a Complex System: Constructive and Dynamic Approach to Cell and Developmental Biology. March 5-6, 2005, University of Tokyo at Komaba.
  • "Replicating vesicles as models of primitive cell growth and division" Martin Hanczyc COST D27 WORKSHOP Prebiotic Chemistry and Early Evolution, Creta. 2004
  • "Replicating vesicles as models of primitive cell growth and division" Martin Hanczyc 228th ACS National Meeting, Philadelphia. 2004
  • "Formation and replication of protocellular compartments" Martin Hanczyc, Shelly Fujikawa, Jack W. Szostak Bridging Nonliving and living matter workshop, Los Alamos National Labs and Santa Fe Institute, 2003

Press:

  • Nature - Oil droplets mimic early life, interview February 23, 2011 with Jo Marchant.
  • New Scientist - Primordial Pac-Man: Oil droplet hints at life's origin, interview, March 2, 2011 by Michael Marshall
  • Scientific American - Oil droplets mimic early life, interview February 23, 2011 with Jo Marchant.
  • Discover Magazine - interviewed and photographed for an article on the origin of life. 2004
  • Chicago Tribune - interviewed by Ronald Kotulak and photographed for an article describing the scientific approaches to the non-living to living matter transition. 2004
  • BBC radio - interviewed by Geoff Watts for the 'Leading Edge' science program regarding my recent findings published in Science. 2003
  • Nova - interviewed and filmed for a public television program on the origin of life. 2002

Last modified 26/09 2013 11:32 by Martin Hanczyc