Rafal Wieczorek

Center for Fundamental Living Technology
Department of Physics, Chemistry and Pharmacy
University of Southern Denmark
Campusvej 55
5230 Odense M
Denmark

Fax +45 6615 8760
Phone +45 6550 3532
Email: rafalatsdu.dk

 

 

Research Interests

I am a biochemist who is currently a postdoctoral research fellow at FLinT Center. My research path is primarily driven by the question of origins-of-life. I would like to know how and why it happened that inanimate matter organized itself into a living entity. This question steers my research interest towards such topics as self-organization, supramolecular chemistry, lipid membranes, small-molecule catalysis and emergence in chemical systems. At FLinT my current research focuses on the development of fatty acid protocells. In particular their functionalization with lipid-anchored DNA information molecules.

I have also interests outside of chemistry. Some of them developed into semi-professional occupations. My website devoted to Easter Island research can be found here.

Short CV

Education

2010: Ph.D. at Dipartimento di Biologia Università degli Studi di Roma Tre, Rome, Italy (supervisor Prof P.L. Luisi)

2007: M.Sc. in Chemistry, Faculty of Chemistry, Warsaw University, Poland, (supervisor Prof. A. Misicka)

2006: M.Sc. in Biotechnology, Faculty of Biology, Warsaw University, Poland, (supervisor Prof. A. Szewczyk, Nencki Institute)

2004: B.Sc. in Biotechnology, Faculty of Biology, Warsaw University, Poland, (supervisor Prof. A. Szewczyk, Nencki Institute)

Scientific experience

2011-present: FLinT Center, University of Southern Denmark; post-doc, DNA-anchors for fatty acid vesicles

2008-2010: Dipartimento di Biologia Università degli Studi di Roma Tre, Italy; short peptide catalysis

2008-2009: Europen Center For Living Technology, Venice, Italy; biogenesis of macromolecular sequences in prebiotic environment

2004-2007: Laboratory of Peptides, Faculty of Chemistry, Warsaw University, Poland; prebiotic synthesis of peptides

2003-2006: Nencki Institute of Experimental Biology, Warsaw, Poland; properties of mitochondria’s inner membrane ion channels

2002-2003: Institute of Biochemistry and Biophysics, Warsaw, Poland; hydrolytic properties of simple peptides

Publications

Wieczorek R, Wamberg MC, Albertsen AN, Löffler PMG, Monnard, P-A. (2013). Bottom–Up Protocell Design: Gaining Insights in the Emergence of Complex Functions. In Pontarotti, P. (Ed.), Evolutionary Biology: Exobiology and Evolutionary Mechanisms, pp. 81-94. Springer Berlin Heidelberg.

Wieczorek R, Dorr M, Chotera A, Luisi PL, Monnard P-A. 2013. Formation of RNA phosphodiester bond by histidine containing dipeptides. ChemBioChem, 14(2):217-223.

Wieczorek R. 2012. On Prebiotic Ecology, Supramolecular Selection and Autopoiesis.Orig Life Evol Biosph, 42(5):445-452.

Gorlero M, Wieczorek R, Adamala K, Giorgi A, Schininà ME, Stano P, Luisi PL. 2009.Ser-His catalyses the formation of peptides and PNAs. FEBS Letters, 583(1):153-6.

Stano P, Gorlero M, Wieczorek R, Chessari S, Luisi PL. 2009 Experimental Approaches to Fragment Condensation.Orig Life Evol Biosph, 39(3-4):270-1.

Luisi PL, Stano P, De Lucrezia D, Wieczorek R, Chiarabelli C. 2009. Chemical Synthetic Biology. Orig Life Evol Biosph, 39(3-4):209.

Skalska J, Piwońska M, Wyroba E, Surmacz L, Wieczorek R, Koszela-Piotrowska I, Zielińska J, Bednarczyk P, Dołowy K, Wilczynski GM, Szewczyk A, Kunz WS. 2008. A novel potassium channel in skeletal muscle mitochondria. Biochim Biophys Acta. 1777(7-8):651-9.